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Chunk #19 — RESULTS — Analysis of the African-American sample

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Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
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Finally, Table 2 shows nominal evidence in AAs for two SNPs in the CHRNA10 region on chromosome 11. For this region, we genotyped SNPs flanking and tagging the gene. While rs2231532 is the most significant in AAs, rs16925377 has modest evidence for consistent association in both AAs and EAs (OR = 1.43 (1.00-2.03), p = 0.049 in AAs and OR = 1.21 (0.99-1.48), p = 0.069 in EAs) (Table 2).