Researchers have begun to evaluate the potential for use of PRS (for a variety of medical phenotypes)11,12 in clinical settings. In this analysis, we examined the current predictive power and strength of association between several PRSs and a variety of SUDs, with a focus on AUD in both a clinically ascertained and a population-based sample. We were interested in (1) which scores based on available GWASs provided the strongest association with alcohol use disorder, whether these scores explained unique variance in AUD in a conditional model, and how well these scores discriminated between cases and controls; (2) what the risk of AUD was for those at the upper end of the risk continuum compared to the bottom; and 3) the levels of substance use disorder criteria for individuals at the top 5% of the polygenic score continuum compared to remaining 95%.
