Chunk #20 — Results — Examining the substance use phenome of the extreme end of the polygenic risk continuum

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Using polygenic scores for identifying individuals at increased risk of substance use disorders in clinical and population samples.

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Overall, individuals in the top 5% of any PRS report greater levels of any substance, though being in the top 5% of the RISK PC PRS is associated with the most other substances. These PRS are modestly correlated with one another in both COGA (rRISK PC* PROB ALC = 0.34; rGSCAN DPW*RISK PC = 0.49; rGSCAN DPW* PROB ALC = 0.40) and FT12 (rRISK PC*PROB ALC = 0.25; rGSCAN DPW*RISK PC = 0.50; rGSCAN DPW* PROB ALC = 0.35), but each captures unique information related to the genetics of substance use problems (and other risky behaviors).