We compared the likelihood of substance-related outcomes in individuals in the top 5% of each of the PRS in COGA and FT12 (adjusted for covariates). Figure 3 presents the mean lifetime criteria endorsed for a variety of substance use disorders (alcohol, cannabis, cocaine, nicotine, and opioid) for individuals in the top 5% for each PRS relative to the bottom 95% of each PRS. In COGA, individuals in the top 5% of the PROB ALC, RISK PC, and/or GSCAN DPW PRS had significantly higher levels of alcohol (0.25–0.31 SD), while individuals in the top 5% of the PROB ALC and RISK PC had higher mean nicotine criteria (0.10–0.16 SD) than those in the bottom 95% of the PRS distribution. Those in the top 5% of the RISK PC PRS also endorsed a higher number of criteria for cannabis use disorder (0.14 SD) and opioid use disorder (0.19 SD). In FT12, those in the top 5% in the top 5% of the RISK PC and GSCAN DPW PRS had significantly higher levels of AUD criteria (0.25–0.31 SD) but did not differ on FTND criteria.
