The ALSPAC resource has a scale and richness that is unprecedented in epidemiological studies. The resource contains key phenotypes, genetic and biological samples collected at multiple time points allowing the assessment of developmental trajectories and critical periods of development. Current data collection focuses on the children’s transition into adulthood, obtaining measures as the children reach their physical maxima and observing emerging patterns in risk taking and anti-social behaviour. Measures have been selected to record the antecedent exposures of future health and psychosocial outcomes. A comprehensive guide can be found on our website.9 Key measures are summarized in Tables 6 and 7. Table 6ALSPAC phenotype measures Self-reported questionnaire measures (from pregnancy to the age of 18 years) Demographics: ethnicityHealth: morbidity, accidents and injuries, medicationPsychological and social: alcohol, smoking and illicit drug use, sexual behaviour, depression, significant life events, parent peer and sibling relationships, peer networks, temperament and behaviourDevelopment: puberty and menstruation, speech and language, fine and gross motor coordinationEducation questionnaires and tests administered in school Understanding of mathematics and science (age 8, 11 and 14 years)SpellingSchool experiences and aspirationsTeacher assessment of
