both in the discovery sample and an independent sample. Converging data provide support for the role of genetic variants within 3q26 in neural hyperexcitability and disorders characterized by impulsivity. In addition, this study demonstrates the utility of the endophenotype approach13; genetic findings of fast beta EEG have provided an underlying biological hypothesis (that is, neural hyperexcitability) that can enhance our understanding of functional cerebral circuits and mechanisms underlying a predisposition to AUD and related behaviors.
