SNPs that fall within zones 3 and 6 are those with associations that are comparable (in size and direction) regardless of educational status and can be thought of as those providing evidence for main genetic associations. The most important observation from this figure is that there are no SNPs in zones 3 and 6; we were not able to replicate the top SNPs across the two groups. To support the main genetic association, we would expect to see SNPs aligned with a 45-degree line (a slope of 1) across this figure, but this is clearly not the case. The same conclusion is reached when referencing the comparable panel on the right, which summarizes the same models but plots the distribution of p values rather than regression coefficients. There are no SNPs in the upper-right quadrant (evidence that the SNP was even moderately significant for both groups) and only a limited number of SNPs that come close to replicating across the two groups. To further contextualize these distributions, we repeated these figures using the simulated environment described earlier; these are plotted
