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Chunk #9 — METHODS — Data analysis — GWAS meta‐analyses

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Neurogenetic and multi-omic sources of overlap among sensation seeking, alcohol consumption, and alcohol use disorder.
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METAL 34 was used to conduct sample size‐weighted GWAS meta‐analyses of non‐overlapping cohort‐level summary statistics for all described meta‐analyses. Genetic correlations confirmed uniformly high concordance between each sample for each phenotype, justifying the meta‐analytic approach (Table S1; see Figure S1 for quantile‐quantile [Q‐Q] plots). Reported effective sample sizes for MVP and PGC and calculated FinnGenR6 effective sample size were used for weighting in the AUD meta‐analysis.