We tested the association of the GRS (described above for SBP, DBP, and PP) with time-to-onset of hypertension. Predictive value of the GRS increased with the number of BP SNPs included (Table 3), as expected. Including SNPs from the meta-analysis of all three cohorts, the SBP GRS was the strongest hypertension predictor with a non-Hispanic white hazards ratio (HR)=1.18 (P=10−44); the DBP GRS was slightly less significant with HR=1.14 (P=10−30), as was that for PP with HR=1.15 (P=10−33). The GRS were also predictive in other groups; e.g., for SBP GRS, Latino P=1.4×10−6, East Asian P=0.0021, and African American P=0.00024.
