paperKB
coga / coga-kb
Help
Sign in

Chunk #16 — Results — Sex Differences

Source
Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.
Embedded
yes

Text

We tested SNP effect size differences by sex (heterogeneity test, Supplementary Table 8; coefficients plot, Supplementary Figure 9). After Bonferroni correction (α=0.00013, all 386 novel and previously-described SNPs), none was significantly different. However, 25 SNPs were nominally significant (P<0.05) at the lead trait, which is in slight excess of the 19.3 expected; of those in the same effect direction in males and females, 17/20 (85.0%, 95% CI=61.1%-96.0%) had stronger magnitude in females than males.