Chunk #27 — Discussion

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Fine mapping of calcineurin (PPP3CA) gene reveals novel alternative splicing patterns, association of 5'UTR trinucleotide repeat with addiction vulnerability, and differential isoform expression in Alzheimer's disease.

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In this report, we describe a more complete image of the structure of the PPP3CA gene. This picture can be linked to convergent data from association, genomic, and expression studies that support roles for PPP3CA, also known as the calcineurin catalytic subunit A, in addiction and in AD.