Examples of TREC I supported TD integration highlight the novelty of this approach. One TREC I supported study identified a statistically significant association of short duration and poor quality of sleep with colorectal polyps, which have the potential to become cancerous [24]. Another TREC I supported study found that participation in a 12-month exercise intervention led to increases in aerobic exercise and aerobic fitness that in turn decreased oxidative stress (which is closely linked to inflammation and cancer), even with minimal changes in body mass and composition [25]. Both of these studies integrated approaches from distinct fields in ways that had not been done before, producing innovative findings. The second study involved collaboration across two of the four TREC I supported research centers.
