In a GWAS of 41,917 BD cases, we identified 64 associated genomic loci, 33 of which are novel discoveries. With a 1.5-fold increase in effective sample size compared with the PGC2 BD GWAS, this study more than doubled the number of associated loci, representing an inflection point in the rate of risk variant discovery. We observed consistent replication of known BD loci, including 28/30 loci from the PGC2 GWAS24 and several implicated by other BD GWAS15,16,17, including a study of East Asian cases59.
