population prevalence of each subtype. These heritability values are significantly different from each other (P = 2.4 × 10−25, block jackknife). The genetic correlation between BD I and BD II was 0.85 (s.e. = 0.05, P = 2.88 × 10−54), which is significantly different from 1 (P = 1.6 × 10−3). The genetic correlation of BD I with schizophrenia (rg = 0.66, s.e. = 0.02) was higher than that of BD II (rg = 0.54, s.e. = 0.05), whereas major depression was more strongly genetically correlated with BD II (rg = 0.66, s.e. = 0.05) than with BD I (rg = 0.34, s.e. = 0.03) (Supplementary Table 22).
