Using electrophysiological measures, a previous linkage study of SNPs within the CHRM2 gene reported highly significant differences for the frontal [Fz] electrode; (p= 0.000009) and p=0.01 at the parietal [Pz] electrode) for the rs1824024 SNP (Jones et al, 2006). Among the 16 SNPs tested within the CHRM2 gene, six showed significance between p = 0.04–0.0003. These data were based on 462 alcohol dependent and 582 non-dependent individuals from the Collaborative Study on the Genetics of Alcoholism (COGA) study. Families included in that report had been selected for multiple cases of alcohol dependence. The present report tested seven SNPs finding only one with statistical significance. However, the importance of the finding may lie in the convergence of evidence across studies.
