Since we replicated two CNVRs using tagging SNPs, their association could have already been detected by genome-wide SNP association studies. Indeed, rs2815752 (tagging CNVR 1p31.1) near NEGR1 is a well-known and well-replicated BMI locus (8,33). In contrast, for rs9804659 (tagging CNVR 11q11), no association to obesity, BMI or waist–hip ratio has yet been reported in the primarily population-based genetic association studies of adults (33,34).
