Administration (FDA) Pharmacogenomics website and the National Cancer Institute (NCI) Cancer Gene Index, resulting in an additional 276 and 6231 interaction claims, respectively (Supplementary Table S1). In addition to these sources, the existing druggable gene category sources were expanded with data extracted from a new druggable genome paper that used computational approaches to identify druggable genes from genome-wide association studies (Supplementary Table S2) (8). The inclusion of this source into the DGIdb results in an additional 2300 potentially druggable genes, a 58% increase from 2.0 (Figure 1). Notably, this independent definition of the druggable genome almost completely encapsulates many other gene categories (e.g. kinases, G-protein coupled receptors) that are expected to be good drug targets (Supplementary Figure S1).
