As the DGIdb has matured, maintaining current representations of existing sources has become increasingly important relative to identifying new interaction sources. Curated updates of drug–gene interaction data from My Cancer Genome and the targeted and biologic therapies for non-small-cell lung cancer (TALC) have occurred, resulting in moderate increases in drug–gene interactions from these sources (9,10). To help prevent regularly updated sources from becoming outdated in the DGIdb, we have rewritten and expanded online updaters to keep frequently updated sources current within the database. With these more frequent, incremental updates to the DGIdb, there has been a substantial increase in drug–gene interaction content from IUPHAR’s Guide to Pharmacology and CIViC, a 23 and 200% increase, respectively (5,11). Additionally, a major update of DrugBank from version 4.3 to 5.0 was performed, resulting in a 30% increase in interaction claims from this source (12). Gene Ontology was also updated which provided a moderate increase for the druggable gene categories (13). For this release, 18 493 new interaction claims were added, of which 50% were from updated sources and 50% from new sources. In
