The locomotor activity was tested as described previously [33, 43, 57] and measured in the SuperFlex Fusion open field cages (40 × 40 × 30 cm, Omnitech Electronics Inc., Columbus, OH). The mice were acclimated to the testing room for 2–3 h and were then allowed to freely explore for 30 min under the illuminated conditions. The movements of mice were monitored by infrared photosensors on the cage and the total distance traveled was analyzed by the Fusion software (Omnitech Electronics Inc., Columbus, OH).
