In AA families, only rs737865 was nominally significant; however, three SNPs gave nominally significant (or nearly so) results in EA families: rs737866, rs4680 and rs174696. Therefore, we applied haplotype analysis to the combination of those three SNPs in both family populations. Bonferroni correction for a total of 8 haplotypes yields a significance threshold of p<0.00625. The A-A-T haplotype in the EA family population was significant in the additive model (Z=2.845; p=0.0044; Table 3). In the AA family population, the G-G-T haplotype was significant in the additive (Z=-3.188; p=0.0014) (Table 3). However, the global p-value was significant only in EA families (p=0.020).
