We then performed haplotype analysis in additional unrelated EA and AA cocaine-dependent individuals, comparing subjects with and without CIP. Both populations showed global significance (p=0.017 in AAs and p=0.0001 in EAs). The frequency distribution for haplotype A-A-T differed significantly between CIP+ and CIP- unrelated AA subjects (p=0.0015 in all subjects, p=0.0004 in males only). Haplotypes A-G-C and A-A-C were significantly different by CIP status in both sexes in EA unrelateds (p=0.0010 and p=0.0003, respectively). The frequency distribution of the A-G-T haplotype was significantly different by CIP status after Bonferroni correction only in male EA unrelateds (p=0.0022) (Table 4 and Supplementary material).
