Table 1 lists AUCmax for a range of complex genetic diseases calculated using equation 3, with calculated using equation 1 from published estimates of K and λS. Despite being observable, the parameters K and λS are subject to considerable sampling variance; we have tried, where possible, to take estimates from reviews or large studies, but large study samples simply do not exist for some low prevalence disorders. The values of AUCmax show that it should be possible for a genomic profile for complex diseases to exceed 0.75, the threshold regarded [20] as making a diagnostic classifier clinically useful when applied to a sample considered to be at increased risk. However, based on the results in Table 1 only the diseases with high heritability and low prevalence, such as Type I diabetes, Crohn's Disease and Lupus, can achieve an AUC, by genomic profiling alone, above the 0.99 threshold regarded [20] as being required for a diagnostic classifier to be applied in the general population. In Table 1, we also consider the AUC expected under scenarios where a genomic profile accounts for
