genomic profiling alone, above the 0.99 threshold regarded [20] as being required for a diagnostic classifier to be applied in the general population. In Table 1, we also consider the AUC expected under scenarios where a genomic profile accounts for only a half (AUChalf) or a quarter (AUCquar) of the known genetic variance. These results show that for rare diseases genomic profiles can be useful classifiers of disease (AUC>0.8 when K<0.01), when the profile explains only a quarter of the genetic variance.
