Using equations (4) and (5) we calculate for the diseases listed in Table 1 when AUC = 0.75. The results (Table 1) show that the same AUC can represent quite different successes of the genomic profile in representing the known genetic variance, ranging from 0.10 to 0.74. If we are able to explain half of the known genetic variance with identified risk variants then genomic profiles for most complex genetic disease (AUChalf, Table 1) will achieve some clinical validity as AUC is >0.75 for all but bladder cancer, for the examples provided.
