the HGNC symbols for candidate genes proposed to mediate those associations. The full list of genes contained within each correlated loci is provided in Supplementary Table 3. Additionally, we used HESS to examine patterns of local genetic correlation in relationship to GWAS hits to make inferences about putative causal directionality between the phenotype-pairs. For all HESS analyses, we used the 1000 Genomes Project Phase 3 European reference panel and the LD-independent genome partitions recommended by the software developers (Berisa & Pickrell 2015). Following the developers’ practices, we assumed no sample overlap for comparisons of data generated by different consortia (Shi et al. 2017).
