sensitive to prenatal alcohol exposure (Mattson et al., 2010b). The specificity of the profile was not tested. The current study aimed to build upon this preliminary neurobehavioral profile to (1) improve our classification accuracy, particularly for alcohol-exposed subjects without FAS and (2) test the specificity of the resulting profile in an alternate clinical group. Using a standardized neuropsychological test battery, we examined children with AE, typically developing controls, and non-exposed children with attention-deficit/hyperactivity disorder (ADHD). A large sample of subjects was assessed at multiple sites using standardized methodology.