Further development of a neurobehavioral profile of fetal alcohol spectrum disorders.
paper
Cited
Public
- Authors
- Mattson, Sarah N; Roesch, Scott C; Glass, Leila; Deweese, Benjamin N; Coles, Claire D; Kable, Julie A; May, Philip A; Kalberg, Wendy O; Sowell, Elizabeth R; Adnams, Colleen M; Jones, Kenneth Lyons; Riley, Edward P; CIFASD
- Year
- 2013
- Journal
- Alcoholism, clinical and experimental research
- PMID
- 22974253
- DOI
- 10.1111/j.1530-0277.2012.01952.x
- PMCID
- PMC3524344
BACKGROUND: Heavy prenatal alcohol exposure (AE) results in a broad array of neurobehavioral deficits. Recent research has focused on identification of a neurobehavioral profile or profiles that will improve the identification of children affected by AE. This study aimed to build on our preliminary neurobehavioral profile to improve classification accuracy and test the specificity of the resulting profile in an alternate clinical group. METHODS: A standardized neuropsychological test battery was administered to 3 groups of children: subjects with AE (n = 209), typically developing controls (CON, n = 185), and subjects with attention-deficit/hyperactivity disorder (ADHD, n = 74). We assessed a large sample from 6 sites in the United States and South Africa, using standardized methodology. Data were analyzed using 3 latent profile analyses including (i) subjects with fetal alcohol syndrome (FAS) and controls, (ii) subjects with AE without FAS and controls, and (iii) subjects with AE (with or without FAS) and subjects with ADHD. RESULTS: Classification accuracy was moderate but significant across the 3 analyses. In analysis 1, overall classification accuracy was 76.1% (77.2% FAS, 75.7% CON). In the second analysis, overall classification accuracy was 71.5% (70.1% AE/non-FAS, 72.4% CON). In the third analysis, overall classification accuracy was 73.9% (59.8% AE, 75.7% ADHD). Subjects that were misclassified were examined for systematic differences from those that were correctly classified. CONCLUSIONS: The results of this study indicate that the neuropsychological effects of AE are clinically meaningful and can be used to accurately distinguish alcohol-affected children from both typically developing children and children with ADHD. Further, in combination with other recent studies, these data suggest that approximately 70% of children with heavy prenatal alcohol exposure are neurobehaviorally affected, while the remaining 30% are spared these often-devastating consequences, at least those in the domains under study. Refining the neurobehavioral profile will allow improved identification and treatment development for children affected by prenatal alcohol exposure.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Immature <i>Caenorhabditis elegans</i> motor neurons control early embryo behavior via both synaptic and nonsynaptic GABA release. | Marvel-Coen J et al. | β | 2026 | β |
| Correlation between metabolite concentrations in the frontal lobes, determined using <sup>1</sup>H-MRS, and IQ in children with foetal alcohol spectrum disorder. | Urbanik A et al. | β | 2025 | β |
| Differentiating Fetal Alcohol Spectrum Disorder from other neurodevelopmental disorders: neurocognitive and socio-emotional evidence. | Fernandes-Magalhaes R et al. | β | 2025 | β |
| Executive and Social Functioning in Fetal Alcohol Spectrum Disorders: Comparison to Autism. | Stagnone NH et al. | β | 2025 | β |
| Trigeminal nerve stimulation (TNS) for children with attention deficit/hyperactivity disorder and fetal alcohol spectrum disorder: Feasibility study protocol. | O'Neill J et al. | β | 2025 | β |
| Using a neural network to derive early childhood neurodevelopmental profiles in the New Hampshire Birth Cohort Study. | Bauer JA et al. | β | 2025 | β |
| Alcohol Toxicity in the Developing Cerebellum. | Mitoma H et al. | β | 2024 | β |
| Polymorphisms in the choline transporter SLC44A1 are associated with reduced cognitive performance in normotypic but not prenatal alcohol-exposed children. | Smith SM et al. | β | 2024 | β |
| Predicting fetal alcohol spectrum disorders in preschool-aged children from early life factors. | Bandoli G et al. | β | 2024 | β |
| Prenatal alcohol exposure and associations with physical size, dysmorphology and neurodevelopment: a systematic review and meta-analysis. | Akison LK et al. | β | 2024 | β |
| The Relationship Between Prenatal, Perinatal, and Postnatal Factors and ADHD: The Role of Nutrition, Diet, and Stress. | Al-Gailani L et al. | β | 2024 | β |
| Brain structural differences in children with fetal alcohol spectrum disorder and its subtypes. | Boateng T et al. | β | 2023 | β |
| Identifying Prenatal Alcohol Exposure and Children Affected by It: A Review of Biomarkers and Screening Tools. | Kable JA et al. | β | 2023 | β |
| Latent classes of neurodevelopmental profiles and needs in children and adolescents with prenatal alcohol exposure. | McLachlan K et al. | β | 2023 | β |
| Racial/Ethnic Disparity in Association Between Fetal Alcohol Syndrome and Alcohol Intake During Pregnancy: Multisite Retrospective Cohort Study. | Oh SS et al. | β | 2023 | β |
| Combining neuroimaging and behavior to discriminate children with attention deficit-hyperactivity disorder with and without prenatal alcohol exposure. | O'Neill J et al. | β | 2022 | β |
| Development and validation of a postnatal risk score that identifies children with prenatal alcohol exposure. | Bernes GA et al. | β | 2022 | β |
| The contribution of the Neurobehavioral Screening Tool to identifying fetal alcohol spectrum disorders in children at high risk of prenatal alcohol exposure and neurobehavioral deficits. | Ronen D et al. | β | 2022 | β |
| Agmatine improves the behavioral and cognitive impairments associated with chronic gestational ethanol exposure in rats. | Aglawe MM et al. | β | 2021 | β |
| Cortical gyrification in children with attention deficit-hyperactivity disorder and prenatal alcohol exposure. | Kilpatrick LA et al. | β | 2021 | β |
| Cross-Sectional Analysis of Spatial Working Memory Development in Children with Histories of Heavy Prenatal Alcohol Exposure. | Moore EM et al. | β | 2021 | β |
| Diagnosis of Fetal Alcohol Spectrum Disorders (FASDs): Guidelines of Interdisciplinary Group of Polish Professionals. | Okulicz-Kozaryn K et al. | β | 2021 | β |
| Effects of prenatal alcohol exposure on cognitive and behavioral development: Findings from a hierarchical meta-analysis of data from six prospective longitudinal U.S. cohorts. | Jacobson JL et al. | β | 2021 | β |
| Ethanol effects on cerebellar myelination in a postnatal mouse model of fetal alcohol spectrum disorders. | Niedzwiedz-Massey VM et al. | β | 2021 | β |
| Ethanol modulation of cerebellar neuroinflammation in a postnatal mouse model of fetal alcohol spectrum disorders. | Kane CJM et al. | β | 2021 | β |
| Examining the effects of prenatal alcohol exposure on corticothalamic connectivity: A multimodal neuroimaging study in children. | Stephen JM et al. | β | 2021 | β |
| MANF is neuroprotective against ethanol-induced neurodegeneration through ameliorating ER stress. | Wang Y et al. | β | 2021 | β |
| Neuroimaging of Supraventricular Frontal White Matter in Children with Familial Attention-Deficit Hyperactivity Disorder and Attention-Deficit Hyperactivity Disorder Due to Prenatal Alcohol Exposure. | Alger JR et al. | β | 2021 | β |
| Neuroinflammatory contribution of microglia and astrocytes in fetal alcohol spectrum disorders. | Kane CJM et al. | β | 2021 | β |
| Polymorphisms in SLC44A1 are associated with cognitive improvement in children diagnosed with fetal alcohol spectrum disorder: an exploratory study of oral choline supplementation. | Smith SM et al. | β | 2021 | β |
| Prenatal alcohol-induced sex differences in immune, metabolic and neurobehavioral outcomes in adult rats. | Bake S et al. | β | 2021 | β |
| The prevalence, child characteristics, and maternal risk factors for the continuum of fetal alcohol spectrum disorders: A sixth population-based study in the same South African community. | May PA et al. | β | 2021 | β |
| Characterizing Alcohol-Related Neurodevelopmental Disorder: Prenatal Alcohol Exposure and the Spectrum of Outcomes. | Coles CD et al. | β | 2020 | β |
| Family reflections: fetal alcohol spectrum disorders. | Cunningham L | β | 2020 | β |
| Fetal Alcohol Spectrum Disorders in a Midwestern City: Child Characteristics, Maternal Risk Traits, and Prevalence. | May PA et al. | β | 2020 | β |
| Maternal Alcohol-Use Disorder and Child Outcomes. | O'Leary C et al. | β | 2020 | β |
| Modification of stem cell states by alcohol and acetaldehyde. | Serio RN et al. | β | 2020 | β |
| Neurodevelopmental Outcomes Associated with Prefrontal Cortical Deoxygenation in Children with Fetal Alcohol Spectrum Disorders. | Kable JA et al. | β | 2020 | β |
| Relationship Between Task-Based and Parent Report-Based Measures of Attention and Executive Function in Children with Fetal Alcohol Spectrum Disorders (FASD). | Mattson JT et al. | β | 2020 | β |
| Unisensory and Multisensory Responses in Fetal Alcohol Spectrum Disorders (FASD): Effects of Spatial Congruence. | Coffman BA et al. | β | 2020 | β |
| Comparing Executive Functioning in Children and Adolescents With Fetal Alcohol Spectrum Disorders and ADHD: A Meta-Analysis. | Khoury JE et al. | β | 2019 | β |
| Differential neuroimaging indices in prefrontal white matter in prenatal alcohol-associated ADHD versus idiopathic ADHD. | O'Neill J et al. | β | 2019 | β |
| Factors predictive of a fetal alcohol spectrum disorder diagnosis: Parent and teacher ratings. | Taylor NM et al. | β | 2019 | β |
| Fetal alcohol spectrum disorder: neurodevelopmentally and behaviorally indistinguishable from other neurodevelopmental disorders. | Lange S et al. | β | 2019 | β |
| Fetal Alcohol Spectrum Disorders: A Review of the Neurobehavioral Deficits Associated With Prenatal Alcohol Exposure. | Mattson SN et al. | β | 2019 | β |
| Fetal alcohol spectrum disorders - diagnostic difficulties in the neonatal period and new diagnostic approaches. | JaΕczewska I et al. | β | 2019 | β |
| Neuropsychiatric and Neurocognitive Manifestations in HIV-Infected Children Treated With Efavirenz in South Africa-A Retrospective Case Series. | Hammond CK et al. | β | 2019 | β |
| Relation Between Oppositional/Conduct Behaviors and Executive Function Among Youth with Histories of Heavy Prenatal Alcohol Exposure. | Doyle LR et al. | β | 2019 | β |
| The Use of Functional Near-Infrared Spectroscopy to Differentiate Alcohol-Related Neurodevelopmental Impairment. | Barrett CE et al. | β | 2019 | β |
| Age-related differences in neuropsychological assessment of fetal alcohol spectrum disorder: a cross-sectional study. | Taylor NM et al. | β | 2018 | β |
| A Pilot RCT of an Internet Intervention to Reduce the Risk of Alcohol-Exposed Pregnancy. | Ingersoll K et al. | β | 2018 | β |
| Comparison of Alcohol-Related Neurodevelopmental Disorders and Neurodevelopmental Disorders Associated with Prenatal Alcohol Exposure Diagnostic Criteria. | Johnson S et al. | β | 2018 | β |
| Does prenatal alcohol exposure cause a metabolic syndrome? (Non-)evidence from a mouse model of fetal alcohol spectrum disorder. | Amos-Kroohs RM et al. | β | 2018 | β |
| Effects of ethanol and varenicline on female Sprague-Dawley rats in a third trimester model of fetal alcohol syndrome. | Montgomery KS et al. | β | 2018 | β |
| Executive Functioning Correlates With Communication Ability in Youth With Histories of Heavy Prenatal Alcohol Exposure. | Doyle LR et al. | β | 2018 | β |
| Fetal regional brain protein signature in FASD rat model. | Davis-Anderson KL et al. | β | 2018 | β |
| [Formula: see text]Factors predictive of a fetal alcohol spectrum disorder: Neuropsychological assessment. | Enns LN et al. | β | 2018 | β |
| Long-term Reductions in the Population of GABAergic Interneurons in the Mouse Hippocampus following Developmental Ethanol Exposure. | Bird CW et al. | β | 2018 | β |
| Mathematics intervention for children with fetal alcohol spectrum disorder: A replication and extension of the math interactive learning experience (MILE) program. | Kully-Martens K et al. | β | 2018 | β |
| Meta-Analyses of Externalizing Disorders: Genetics or Prenatal Alcohol Exposure? | Wetherill L et al. | β | 2018 | β |
| Prenatal Alcohol Exposure Increases Histamine H<sub>3</sub> Receptor-Mediated Inhibition of Glutamatergic Neurotransmission in Rat Dentate Gyrus. | Varaschin RK et al. | β | 2018 | β |
| Study protocol for a self-controlled cluster randomised trial of the Alert Program to improve self-regulation and executive function in Australian Aboriginal children with fetal alcohol spectrum disorder. | Wagner B et al. | β | 2018 | β |
| Altered functional connectivity during spatial working memory in children with heavy prenatal alcohol exposure. | Infante MA et al. | β | 2017 | β |
| Attention and working memory training: A feasibility study in children with neurodevelopmental disorders. | Kerns KA et al. | β | 2017 | β |
| BDNF concentrations and daily fluctuations differ among ADHD children and respond differently to methylphenidate with no relationship with depressive symptomatology. | Cubero-MillΓ‘n I et al. | β | 2017 | β |
| Dietary choline levels modify the effects of prenatal alcohol exposure in rats. | Idrus NM et al. | β | 2017 | β |
| Fetal alcohol spectrum disorder in Africa. | Adnams CM | β | 2017 | β |
| Fetal Alcohol Spectrum Disorders: A Case Study. | Glass L et al. | β | 2017 | β |
| [Formula: see text]Parent rating of executive function in fetal alcohol spectrum disorder: A review of the literature and new data on Aboriginal Canadian children. | Rai JK et al. | β | 2017 | β |
| Functional connectivity abnormalities and associated cognitive deficits in fetal alcohol Spectrum disorders (FASD). | Wozniak JR et al. | β | 2017 | β |
| Ifenprodil infusion in agranular insular cortex alters social behavior and vocalizations in rats exposed to moderate levels of ethanol during prenatal development. | Bird CW et al. | β | 2017 | β |
| Neurodevelopmental profile of Fetal Alcohol Spectrum Disorder: A systematic review. | Lange S et al. | β | 2017 | β |
| Prefrontal cortical responses in children with prenatal alcohol-related neurodevelopmental impairment: A functional near-infrared spectroscopy study. | Kable JA et al. | β | 2017 | β |
| Prevalence and profile of Neurodevelopment and Fetal Alcohol Spectrum Disorder (FASD) amongst Australian Aboriginal children living in remote communities. | Fitzpatrick JP et al. | β | 2017 | β |
| Self-reported health, use of alcohol and illicit drugs, and criminality among adults with foetal alcohol syndrome. | Rangmar J et al. | β | 2017 | β |
| The Use of Cardiac Orienting Responses as an Early and Scalable Biomarker of Alcohol-Related Neurodevelopmental Impairment. | Mesa DA et al. | β | 2017 | β |
| Transcriptome Profiling Identifies Ribosome Biogenesis as a Target of Alcohol Teratogenicity and Vulnerability during Early Embryogenesis. | Berres ME et al. | β | 2017 | β |
| Abnormal Eating Behaviors Are Common in Children with Fetal Alcohol Spectrum Disorder. | Amos-Kroohs RM et al. | β | 2016 | β |
| A Decision Tree to Identify Children Affected by Prenatal Alcohol Exposure. | Goh PK et al. | β | 2016 | β |
| Alcohol exposure in utero is associated with decreased gray matter volume in neonates. | Donald KA et al. | β | 2016 | β |
| Alcohol Intervention for Adolescents with Fetal Alcohol Spectrum Disorders: Project Step Up, a Treatment Development Study. | O'Connor MJ et al. | β | 2016 | β |
| Effects of sex and housing on social, spatial, and motor behavior in adult rats exposed to moderate levels of alcohol during prenatal development. | Rodriguez CI et al. | β | 2016 | β |
| Fetal alcohol spectrum disorders: Prevention, identification, and intervention. | Walker DS et al. | β | 2016 | β |
| Inflammatory responses to alcohol in the CNS: nuclear receptors as potential therapeutics for alcohol-induced neuropathologies. | Kane CJ et al. | β | 2016 | β |
| Interhemispheric Functional Brain Connectivity in Neonates with Prenatal Alcohol Exposure: Preliminary Findings. | Donald KA et al. | β | 2016 | β |
| Peroxisome Proliferator-Activated Receptor-Ξ³ Agonists: Potential Therapeutics for Neuropathology Associated with Fetal Alcohol Spectrum Disorders. | Drew PD et al. | β | 2016 | β |
| Research Review: Executive function deficits in fetal alcohol spectrum disorders and attention-deficit/hyperactivity disorder - a meta-analysis. | Kingdon D et al. | β | 2016 | β |
| Updated Clinical Guidelines for Diagnosing Fetal Alcohol Spectrum Disorders. | Hoyme HE et al. | β | 2016 | β |
| Advances in Diagnosis and Treatment of Fetal Alcohol Spectrum Disorders: From Animal Models to Human Studies. | Murawski NJ et al. | β | 2015 | β |
| Anterior cingulate cortex surface area relates to behavioral inhibition in adolescents with and without heavy prenatal alcohol exposure. | Migliorini R et al. | β | 2015 | β |
| Biomarkers in substance use disorders. | Volkow ND et al. | β | 2015 | β |
| Clinical sensitivity and specificity of meconium fatty acid ethyl ester, ethyl glucuronide, and ethyl sulfate for detecting maternal drinking during pregnancy. | Himes SK et al. | β | 2015 | β |
| Cognitive factors contributing to spelling performance in children with prenatal alcohol exposure. | Glass L et al. | β | 2015 | β |
| Ethanol exposure induces a delay in the reacquisition of function during head regeneration in Schmidtea mediterranea. | Lowe JR et al. | β | 2015 | β |
| Executive Functioning in Children and Adolescents Prenatally Exposed to Alcohol: A Meta-Analytic Review. | Khoury JE et al. | β | 2015 | β |
| Fetal alcohol spectrum disorders among children in a Brazilian orphanage. | StrΓΆmland K et al. | β | 2015 | β |
| Maternal iron deficiency worsens the associative learning deficits and hippocampal and cerebellar losses in a rat model of fetal alcohol spectrum disorders. | Huebner SM et al. | β | 2015 | β |
| Moderate prenatal alcohol exposure enhances GluN2B containing NMDA receptor binding and ifenprodil sensitivity in rat agranular insular cortex. | Bird CW et al. | β | 2015 | β |
| Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Review of Evidence and Guidelines for Assessment. | Doyle LR et al. | β | 2015 | β |
| Objective assessment of ADHD core symptoms in children with heavy prenatal alcohol exposure. | Infante MA et al. | β | 2015 | β |
| The effects of prenatal exposure to alcohol and environmental tobacco smoke on risk for ADHD: a large population-based study. | Han JY et al. | β | 2015 | β |
| Automated cerebellar segmentation: Validation and application to detect smaller volumes in children prenatally exposed to alcohol. | Cardenas VA et al. | β | 2014 | β |
| Effects of moderate prenatal ethanol exposure and age on social behavior, spatial response perseveration errors and motor behavior. | Hamilton DA et al. | β | 2014 | β |
| Fetal alcohol spectrum disorders. | DΓΆrrie N et al. | β | 2014 | β |
| Fetal alcohol spectrum disorders and neuroimmune changes. | Drew PD et al. | β | 2014 | β |
| Foetal alcohol spectrum disorder: identifying the neurobehavioural phenotype and effective interventions. | Koren G et al. | β | 2014 | β |
| High-throughput transcriptome sequencing identifies candidate genetic modifiers of vulnerability to fetal alcohol spectrum disorders. | Garic A et al. | β | 2014 | β |
| Inappropriate feeding behaviors and dietary intakes in children with fetal alcohol spectrum disorder or probable prenatal alcohol exposure. | Werts RL et al. | β | 2014 | β |
| Longitudinal MRI reveals impaired cortical thinning in children and adolescents prenatally exposed to alcohol. | Treit S et al. | β | 2014 | β |
| Neural crest development in fetal alcohol syndrome. | Smith SM et al. | β | 2014 | β |
| Neurobehavioral, neurologic, and neuroimaging characteristics of fetal alcohol spectrum disorders. | Glass L et al. | β | 2014 | β |
| Prenatal alcohol exposure and adolescent stress - unmasking persistent attentional deficits in rats. | Comeau WL et al. | β | 2014 | β |
| The clinical utility and specificity of parent report of executive function among children with prenatal alcohol exposure. | Nguyen TT et al. | β | 2014 | β |
| The importance of measurement precision and behavioral homologies in evaluating the behavioral consequences of fetal-ethanol exposure: commentary on Williams and colleagues ("Sensory-motor deficits in children with fetal alcohol spectrum disorder assessed using a robotic virtual reality platform"). | Hamilton DA | β | 2014 | β |
| Ethanol alters the balance of Sox2, Oct4, and Nanog expression in distinct subpopulations during differentiation of embryonic stem cells. | Ogony JW et al. | β | 2013 | β |
| Magnetic resonance microscopy-based analyses of the neuroanatomical effects of gestational day 9 ethanol exposure in mice. | Parnell SE et al. | β | 2013 | β |
| Neuropsychological deficits associated with heavy prenatal alcohol exposure are not exacerbated by ADHD. | Glass L et al. | β | 2013 | β |