region of the brain that is particularly susceptible to the effects of long-term alcohol abuse and include genes involved in myelination, ubiquitination, apoptosis, cell adhesion, neurogenesis, and neural disease. Genes involved in neurodegenerative diseases such as Alzheimer disease were also significantly altered, suggesting a link between alcoholism and other neurodegenerative conditions. The mechanism by which chronic alcohol abuse results in these changes in gene expression remains unknown.
