We conclude that the TOCS is useful for studying both an overall OC trait and individual dimensions. This measure identified several heritable OC dimensions similar to those in previous studies. OC dimensions were correlated to a significant extent, but appeared to have different etiological mechanisms. Even less phenotypically correlated dimensions shared genetic risk. We are currently working on a genome-wide association study of OC traits in this sample to uncover whether genetic variants are associated similarly across OC dimensions. Specifically, we will test if Hoarding and Cleaning/Contamination are differentially associated with genetic variants. To uncover the genetics of OC traits and OCD, OC trait dimensions should be considered both individually and together.
