To test whether multiple susceptibility alleles with small effects were organized into pathways, we used Consensus-PathDB, a human-centric meta-database of functional biological data compiled from 30 separate public sources of biological interactions.17–19 A list of 265 genes overlapping or flanking (±25 kilobases [kb]) the SCZ-associated SNPs with P<.05 in our analysis were included in these analysis. To account for multiple testing, we controlled the false discovery rate20 at the 0.01 level (eMethods 2 and eTable 3).
