In MIND, sources of prior information used to select SNPs through data integration will only affect results to the extent that they contain disease-relevant information (ie, to the extent that genes with good P values in the sources of prior information also have good P values in the meta-analysis) (eMethods 3). Because most of the databases we used pertain to genes, bias in terms of selecting SNPs in genes as opposed to intergenic regions is expected. However, the selection was entirely based on the empirical support for SNPs in those genes. Furthermore, the pathway analyses were performed using the replication results. Therefore, our pathway findings are unlikely to reflect prior notions about SCZ-relevant pathways for which there is no empirical support (eFigure 9).
