Of critical importance, we observed significant evidence of SNP effect sizes in the replication data in the same direction as the discovery set (55/72 signals, sign test binomial P=4×10-6). This enrichment was also observed for the AN restricting (58/72, P=8×10-8) and binge-purge (56/72, P=1×10-6) subtype analyses. These results strongly indicate that the prioritized set of variants is likely to contain true positive signals for AN but that the current sample size is insufficient to detect these effects.
