genes). For each module, the eigengene was obtained based on the first principle component and thus summarizes the expression of all genes within a module across all samples in Braak stage-related regions R1–R6. This was done for each brain donor separately. The sign of the eigengene expression was corrected based on the sign of its Pearson’s correlation with the mean expression of all genes within the module. Similar to the BRGs, the eigengene of each module was correlated with Braak stage labels for each donor separately and correlations were combined across donors using meta-analysis.
