Cannabinoids have been shown to decrease evoked and spontaneous GABAergic synaptic transmission onto BLA principal neurons. Within BA principal neurons, Katona et al. demonstrated that the amplitude of evoked GABA-A receptor-mediated inhibitory post-synaptic currents (eIPSC) are depressed by application of the CB1 agonists Win 55212-2 and CP 55940; effects that were reversed by the CB1 receptor antagonist SR141716 (Katona et al., 2001). Similarly, Win 55212-2 was unable to suppress GABAergic transmission in CB1−/− mice. Moreover, Win 55212-2 also decreased the frequency and conductance of spontaneous, action potential-driven IPSCs (sIPSC). Azad et al. found a similar affect of CB1 receptor activation on eIPSCs recorded from mouse LA principal neurons (Azad et al., 2003).
