A summary of the regional and subcellular expression of various eCB signaling components is diagramed in figure 1a and b. In general, the BLA expresses eCB signaling molecules in a distribution pattern common to other cortical brain regions. Specifically, the BLA exhibits high CB1-expression by a subset of large CCK+ GABAergic interneurons, and low levels of expression by principal neurons. FAAH and MGL are expressed post-synaptically and presynaptically, respectively. DAGLα is expressed by principal neurons, and appears to cluster at invaginating synapses that receive GABAergic inputs from CB1+/CCK+ interneurons. The CeA exhibits staining more similar to that of the striatum, although more detailed subcellular studies are lacking in this brain region.
