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Chunk #33 — RESULTS — Gene prioritization and RNA expression analysis

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Genome-wide association studies of the self-rating of effects of ethanol (SRE).
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For chromosome 11, one variant (rs2270678, COGA-AA+EA p=1.81E-08) was located in the 5’ UTR of PRMT3 (protein arginine methyltransferase 3). Another variant (rs3781679, COGA-AA+EA p = 3.58E-05, Table S1) was located in the 3’ UTR of HTATIP2 (HIV-1 Tat interactive protein 2). Therefore, both genes were prioritized in FUMA. Chromatin interaction mapping further prioritized DBX1 (developing brain homebox 1) and SLC6A5 (solute carrier family 6 member 5) in this region. On chromosome 6, three variants were located in the 3’ UTR of AFDN (adherens junction formation factor) (Table S1) and this gene was therefore prioritized by FUMA. eQTL analysis further prioritized the gene KIF25 (kinesin family member 25) in this region (multiple variants had FDR<0.01). No genes were prioritized in the chromosome 13 region.