For the six genes prioritized by FUMA (Chromosome 11: PRMT3, HTATIP2, DBX1, SLC6A5; Chromosome 6: AFDN, KIF25), RNA expression in brain tissue obtained from NSWBRTC was examined. After adjusting for six tests, the Bonferroni correction threshold was set at p<0.0083. Rs140154945 did not pass QC in this smaller postmortem tissue sample, therefore the next most significant variant in high LD (rs3778662, COGA-EA p=7.24E-08, r2=0.92 with rs140154945) was used. After adjustment for covariates, including AD status of decedent, rs3778662 was identified as an eQTL of KIF25 (p=6.62E-05).
