PRS analysis results are summarized in Table 4. For both SRE-T and SRE-5, there are four discovery-test dataset pairs (i.e., Bonferroni p<0.0125). Overall, PRS from SRE-T outperformed those from SRE-5 in prediction of AD phenotypes; PRS of both SRE-T and SRE-5 predicted greater variance in DSM-IV AD criterion count than AD; prediction was also higher in EA than in AA samples. The strongest finding was for polygenic scores based on the COGA-EA SRE-T GWAS, which predicted 2.48% of the variance in AD in the SAGE-EA.
