This is the first GWAS to identify common variants associated with SRE-T and the first GWAS of SRE scores in AA samples. This is also the first study to report genomewide significant findings for any SRE score. These findings are not under linkage regions previously published (Ehlers et al., 2010, Schuckit et al., 2001) using SRE-5. Of the genomewide significant loci, the locus on chromosome 11 was nominally replicated in one sample, although the replication sample was small. Of the genes prioritized for SRE-T in the EA sample, KIF25 was supported by data from both in silico functional analyses and RNA expression analysis. In addition, PRS derived from these discovery GWAS of SRE predicted variance in AD-related phenotypes in independent datasets. Broadly, these GWAS analyses suggest that larger samples of SRE phenotypes, particularly SRE-T, might be highly informative in the identification of loci related to LR, which influences risk for development of AD and is emerging as a notable target for prevention.
