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Chunk #12 — Results — Top Bipolar Disorder susceptibility SNPs from GWA studies are enriched for mQTLs

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Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants.
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We then tested for cis mQTL enrichment for all SNP-disease associations satisfying p < 0.0001. Such a test would establish robustness of our observation to the definition of “top SNP associations” used in the analysis. We found that the cis mQTL enrichment held robustly (p = 0.01) at the more stringent SNP-disease association cutoff.