In the example multivariate analyses shown in Figs 7-8, canonical correlation analysis (CCA32) combined with independent component analysis (ICA33) is used to identify several “modes” of population covariation which link multiple brain IDPs to sets of other Biobank variables. This is very similar to the methodology used recently to identify a single mode of population covariation between imaging measures and many behavioral and lifestyle measures in data from 461 subjects in the Human Connectome Project8, 34.
