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Chunk #28 — Results — Whole genome sequence fine-mapping of the 108 PGC loci

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Psychophysiological endophenotypes to characterize mechanisms of known schizophrenia genetic loci.
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In the whole genome sequence variant call set we discovered 203 905 variants within the 108 loci identified by and defined by the PGC (Schizophrenia Working Group of the Psychiatric Genomics Consortium, 2014). We again employed a liberal multiple-testing correction (0.05/203 905 = 2.5 × 10−7) that corrected only for the number of SNPs within these loci and ignored multiple phenotypes. Even at this liberal threshold, we found no significant association between any variant in these loci and any of the 17 endophenotypes.