Identified FAIRE-seq enriched regions residing in proximity to each other, have been traditionally merged together using BedTools [141] (for detailed instructions read [142]) to form Clusters of Open Regulatory Elements (COREs) (Step 11) [91, 94, 95]. Formation of COREs allows the identification of chromatin accessibility and gene regulation patterns that may have otherwise remained undetectable in a smaller genomic scale. COREs can be also generated from all other chromatin accessibility datasets.
