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Chunk #6 — Introduction

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Resting-state EEG source localization and functional connectivity in schizophrenia-like psychosis of epilepsy.
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In this study, we sought to determine abnormal patterns of resting-state EEG oscillatory activity and functional connectivity in patients with SLPE using lagged phase synchronization, a novel nonlinear connectivity measure implemented in the free academic eLORETA software. We also aimed at assessing whether abnormalities in functional connectivity in SLPE correlate with psychopathological disturbance. Based on previous findings in schizophrenia, our working hypothesis was that during resting state, in addition to regional cortical dysfunction, disruption in functional connectivity may also occur in patients with SLPE affecting areas of the DMN as well as cortical regions critical to psychosis, and that some altered connections between brain areas may correlate with psychopathology measures.