parent drug dependent or depressed did not elevate adolescent AD when tested within this model. When adolescent AD was tested in a model that simultaneously evaluated parental AD and multiplex risk status, only membership in a multiplex family showed a trend indicating an association (Wald = 3.66, df = 1, p=0.056). However, when either alcohol or drug dependence in adolescence was considered as the outcome variable, only parental alcohol dependence was associated with increased risk (Wald = 7.82, df =1, p=0.005); familial risk was not.
