A combined model was used to evaluate the effects of risk status, parental alcohol or drug dependence, and parental depression on adolescent outcome (MDD and AD). Comparisons were made adjusting for number of siblings and the number of repeated measures. For the presence of MDD in adolescence, presence of parental alcohol or drug dependence, depression, and familial risk status were entered into the model to determine the significance of each of the variables to the model. This analysis revealed that MDD in adolescent offspring showed a significant association for only the case where either parent was alcohol dependent (Wald = 6.50, df =1, P = 0.011). The same parental variables when entered for adolescent AD outcome by age 18 showed a significant association with having either parent alcohol dependent (Wald = 7.07, df = 1, P = 0.008). Having either parent drug dependent or depressed did not elevate adolescent AD when tested within this model. When adolescent AD was tested in a model that simultaneously evaluated parental AD and multiplex risk status, only membership in a multiplex family showed a
