Exclusion criteria were as follows: current DSM-IV criteria for drug dependence (excluding nicotine) by verbal report and urine drug screens, other major DSM-IV Axis I disorders, psychoactive medication or substance use (except marijuana) in the past 30 days or a positive urine drug screen, current suicidal or homicidal ideation, past history of alcohol-related medical illness, liver enzymes ≥ 3 times above normal, or significant health problems.