The Investigational Review Board approved this study and subjects signed informed consent. Genotyping was done within 5 days of blood draw. All subjects with the 118 AG (asn40asp) or 118 GG (asp40asp) genotype, and those matched/yoked to them (see below) who had the 118 AA (asn40asn) genotype were asked to return in 2-3 days for further evaluation with a number of standard interview, questionnaire, and medical diagnostic procedures as previously reported by our group (Anton et al., 2004; Voronin et al., 2008). Interview procedures included a demographic form, the SCID (First MB et al., 1997) and a timeline follow-back interview (Sobell et al., 1988) to quantify drinking during the preceding 90 days. The Obsessive-Compulsive Drinking Scale (OCDS) (Anton et al., 1996) and the Alcohol Dependence Scale (ADS) (Skinner and Allen, 1982) were administered. Finally, a urine drug screen, blood tests for health screening, and a physical exam were conducted.
