that neuronal remodelling and plasticity might play during neuroadaptation to chronic alcohol consumption. Furthermore, ubiquitination-related activities were highlighted as significantly enriched molecular functions in the core of 17 over-targeted mRNAs, which underscores the importance of the proteasome system. An unexpected result from the functional enrichment analysis was the inverse relationship detected between a subset of 27 downregulated mRNA targets and upregulated Alzheimer’s disease genes (Blalock et al., 2004) (Table 4, Coexpression Gene Sets). Interestingly, there is growing body of evidence describing a neuroprotective role for moderate alcohol drinking that significantly reduces the risk of either cognitive decline or dementia, including Alzheimer’s disease (Collins et al., 2009). Table 5 shows the lists of downregulated genes that scored significantly enriched in DAVID GO categories and KEGG pathways.
