The current study examined the effectiveness of a set of brief, web-based alcohol prevention programs for reducing risky drinking behaviors in a college freshman sample, focusing on whether an individually tailored program based on the LR to alcohol had a greater impact on alcohol use behaviors than a non-targeted “state of the art” program. Our first hypothesis was that individuals with low LR would experience greater reductions in alcohol use when enrolled in the tailored LRB program, as was previously reported by Schuckit et al. (2012, 2015). The evidence of an interaction between program and level of response in predicting changes in alcohol use was limited, with a significant interaction observed only for maximum drinks per day among participants who completed all program modules. Thus our overall results did not support robust effects associated with matching individuals to a targeted program based on level of response to alcohol, but these LR-tailored prevention programs may have incremental effects over standard programs when protocol adherence – and exposure to the educational content – is high. However, our results do support the effectiveness
